The F1 champions teamed up yet again to stretch their unbeaten record in the competition, a trophy they first won back in 2007 during Schumacher's first retirement and when Vettel was starting his F1 career with Toro Rosso.
Schumacher and Vettel competed in a variety of machinery to make the final at Thailand's Rajamangala Stadium in Bangkok.
The German duo beat Team France in the final, with Schumacher defeating Lotus driver Romain Grosjean and Vettel edging out WRC star Sebastien Ogier.
"It's a historic day, six in a row is very special. I was pretty scared of France. Our consistency made the difference," said Schumacher.
"It's a privilege to be here and race these guys", added Vettel. "I'm looking forward to staying in as long as possible tomorrow!"
The competition continues with the main event on Sunday when the drivers compete individually for the title of 'Champion of Champions', with neither Vettel nor Schumacher having won the individual trophy.
Ogier will defend that title tomorrow.
Among the other competitors were IndyCar champion Ryan Hunter-Reay, double MotoGP king Jorge Lorenzo, as well as former F1 winner David Coulthard.