Despite hoping to find a new seat after being replaced at Williams by Valtteri Bottas, the Brazilian has been signed up for 2013 by Aston Martin's sports car team.
The David Richards-led Aston Martin Racing said Senna, 29, will "drive at each round of the WEC" this year. WEC is the FIA's world endurance championship, including the fabled Le Mans 24 hours.
Senna is quoted by Brazil's O Estado de S.Paulo: "Until 2009, I always had victories and podiums in the categories I passed.
"Since then, through a series of circumstances beyond my control, I did not have the same chance in Formula 1.
"The proposals offered to me this season also did not give me this possibility."